Mucus Overproduction Virus-Induced Airway Hyperreactivity and CXCR2 Regulates Respiratory Syncytial
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چکیده
منابع مشابه
Building a better neonatal mouse model to understand infant respiratory syncytial virus disease
BACKGROUND Respiratory syncytial virus (RSV) is the number one cause of lower respiratory tract infection in infants; and severe RSV infection in infants is associated with asthma development. Today, there are still no vaccines or specific antiviral therapies against RSV. The mechanisms of RSV pathogenesis in infants remain elusive. This is partly due to the fact that the largely-used mouse mod...
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Human respiratory syncytial virus (HRSV) is the leading cause of respiratory failure and viral death in infants (Thompson et al., 2003). In HRSV bronchiolitis, plugs of mucus, epithelial cell debris, and innate inflammatory cells obstruct the airways leading to pulmonary obstruction (Aherne et al., 1970; Lugo and Nahata, 1993). In autopsy lung tissues from fatal HRSV disease cases, epithelial d...
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